Evo 2 / 40B parameters / 9T base pairs

Co-design genomes withan IDE that thinks out loud

Paste a sequence. Watch Evo 2 annotate, score, and fold it in real time. Click any base for instant feedback.

Get started GitHub
Base pair editing

Editable biology

Click any base. See the consequence.

Edit T to G at position 121,452,891. Affinity, stability, and variant impact re-score in under two seconds. Every edit is versioned.

Realtime scoringPartial re-runsVersion history

Multi-dimensional scoring

Every candidate evaluated across four orthogonal dimensions.

94.2
BDNF_reg_v4#001
Functional
Sequence plausibility
94%
+2.1High
Tissue
Expression specificity
82%
+0.8Moderate
Off-target
Unwanted activity risk
0.04%
-0.01Low risk
Novelty
Sequence originality
67%
+5.2Acceptable

Structure prediction

From sequence to structure

AlphaFold 3 folds top candidates into 3D protein structures with per-residue confidence. Rendered in-browser. ColabFold local fallback when rate-limited.

Protein structure

From weeks of workto minutes.

The interface layer genomic design has been missing.

Open Helix IDE